Quinone methides: useful reactive intermediates for DNA cross-linking and organic synthesis
نویسنده
چکیده
We investigated the reactivity of several quinone methides (QMs) as activatable bis-alkylating agents capable of DNA cross-linking (XL-DNA) with promising potency. Taking advantage from a photochemical activation protocol of BINOL-derivatives, we had developed a new method for the resolution of 3,3’-CH2Xdisubstituted BINOL (X = NR2, SR, OH) studying as well the effect of electron-donating and electronwithdrawing on the reactivity of QM and on the stability of the adducts formed.
منابع مشابه
Quinone methide intermediates in organic photochemistry*
Quinone methides are widely encountered reactive intermediates in the chemistry of phenols and related compounds. This paper summarizes our recent progress in uncovering new and general photochemical methods for forming quinone methides of various structural types in aqueous solution. Their mechanism of formation and subsequent chemistry are also discussed. New examples of excited-state intramo...
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تاریخ انتشار 2007